Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzoyl chloride, 3,4,5-trimethoxy- | HCID 78282 | — |
| Reactant | HCID 178509021 | HCID 178509021 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 178492676 | HCID 178492676 | 90.4% |
Reaction Steps
12.9 g of 5-fluorocytosine was suspended in 78 ml of pyridine, followed by addition of 23.1 g of 3,4,5-trimethoxybenzoyl chloride and stirring at 100° C. for 5 hours. The reaction mixture was cooled down to room temperature and then poured into 310 ml of water at room temperature over a period of 20 minutes. The precipitated crystals were collected by filtration to obtain 29.2 g (90.4%) of 5-fluro-N4 -(3,4,5-trimethoxybenzoyl)cytosine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05453497 |
|---|
| Source dataset | uspto-grants-1995_09 |
|---|
| ORD ID | ord-17bf57979d154eaf9743da8f3f9d9e25 |
|---|
| Source note | uspto-grants-1995_09 |
|---|
