Cyanamide → HCID 19382714, compound
Reaction equation
[N:1]#[C:2][NH2:3].Cl.[Cl:5][CH2:6][CH2:7][CH2:8][C:9]1[C:10]([CH3:15])=[N:11][NH:12][C:13]=1[CH3:14]>O.C(O)C>[ClH:5].[Cl:5][CH2:6][CH2:7][CH2:8][C:9]1[C:13]([CH3:14])=[N:12][N:11]([C:2]([NH2:3])=[NH:1])[C:10]=1[CH3:15]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 80 °C
Procedure
A solution of 0.17 g of cyanamide in 0.3 ml of water was added to a solution of 0.46 g of 4-(3-chloropropyl)-3,5-dimethyl-1H-pyrazole hydrochloride in 5 ml of ethanol, and the reaction mixture was stirred for one day at 80° C. the solvent was removed by distillation under reduced pressure, and the resulting residue was recrystallized from isopropanol-diisopropylether to obtain 0.13 g of 4-(3-chloropropyl)-3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride.
Workup
- customwas removed by distillation under reduced pressure
- customthe resulting residue was recrystallized from isopropanol-diisopropylether
Sources & evidence
- ORD record
- ord-eca47fdcf51047baa8d0474169694750
- Source dataset
- uspto-grants-1995_09
- Patent number
- US05453514
Reaction notes
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