HCID 67780663, compound → HCID 19382738, compound

HRID 2400156Notes

Reaction equation

HRID 2400156 reaction equation
[ClH:1].[NH2:2][C:3]1[N:7]([C:8]([NH2:10])=[NH:9])[N:6]=[C:5]([CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:4]=1>CO.[H][H].[C].[Pd]>[ClH:1].[NH2:2][C:3]1[N:7]([C:8]([NH2:10])=[NH:9])[N:6]=[C:5]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:4]=1

Participants

5

Reactant 1

HCID 67780663HCID 67780663, compound

Product 1

HCID 19382738HCID 19382738, compoundYield 62.9%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

0.1 g of 10% palladium-carbon were added to a solution of 0.6 g of 5-amino-3-(2-phenylethenyl)-1H-pyrazole-1-carboxamidine hydrochloride in 40 ml of methanol and stirred for 30 minutes in hydrogen atmosphere of normal pressure at room temperature. The reaction solution was filtered to remove the insoluble solids therefrom, and the solvent was removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol-ether to obtain 0.38 g of 5-amino-3-(2-phenylethyl)-1H-pyrazole-1-carboxamidine hydrochloride.

Workup

  1. filtrationThe reaction solution was filtered
  2. customto remove the insoluble solids
  3. customthe solvent was removed by distillation under reduced pressure
  4. customThe resulting residue was recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-a19b9669562b4adeab06ca9e1697c097
Source dataset
uspto-grants-1995_09
Patent number
US05453514

Reaction notes

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