Bromine → HCID 19972720, compound

Participants

Reaction Steps

A solution of 11.2 g of bromine in 250 ml of chloroform was added, over a period of two hours at 20°-25° C., to a solution of 19.5 g of Intermediate III in 700 ml of chloroform. After stirring for 1 hour at 20°-25° C., the solution was washed with 400 ml of an aqueous 2N sodium hydroxide solution and then repeatedly with water, dried with anhydrous sodium sulphate and stripped in vacuo. The crude product was treated with diethyl ether, collected by suction filtration and crystallized from acetone, to give 16 g of the title compound, melting point 134°-135° C.

Provenance & Evidence