Thionyl Chloride → HCID 19972458, compound

HRID 2400165Notes

Reaction equation

HRID 2400165 reaction equation
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][N:8]([CH3:29])[C:9]([C:11]1[C:20]2[O:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:17]([CH3:27])[C:16](=[O:28])[C:15]=2[CH:14]=[CH:13][CH:12]=1)=[O:10]>ClCCl.C(OCC)C>[Cl:3][CH2:6][CH2:7][N:8]([CH3:29])[C:9]([C:11]1[C:20]2[O:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:17]([CH3:27])[C:16](=[O:28])[C:15]=2[CH:14]=[CH:13][CH:12]=1)=[O:10]

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 19972386HCID 19972386, compound

Product 1

HCID 19972458HCID 19972458, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent2×

Procedure

A solution of 1.1 ml of thionyl chloride in 2 ml of dichloromethane was added to a solution of 3.37 g of Intermediate VI in 20 ml of dichloromethane, and the mixture was stirred for 4 hours at ambient temperature. The removal of the solvent in vacuo gave an oil which was taken up in diethyl ether. 3 g of the title compound precipitated as a white solid which was filtered and used with no further purification. Melting point 126°-128° C. (diethyl ether).

Workup

  1. customThe removal of the solvent in vacuo
  2. customgave an oil which
  3. custom3 g of the title compound precipitated as a white solid which
  4. filtrationwas filtered
  5. customused with no further purification

Sources & evidence

ORD record
ord-a4147d7867524d0a9733f1a5f9ce1580
Source dataset
uspto-grants-1995_09
Patent number
US05453518

Reaction notes

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