Triethylamine → HCID 19972408, compound

Participants

Reaction Conditions

Reaction Steps

53.4 g of Intermediate II and 38.8 ml of anhydrous triethylamine were dissolved in 440 ml of chloroform. A solution of 19.8 ml of thionyl chloride in 80 ml of anhydrous chloroform was added to the above solution, which was maintained at -10°/-2° C. The reaction mixture was stirred at ambient temperature for 4 hours, and then diluted with 400 ml of water. The aqueous phase was extracted with chloroform, and the extracts were added to the chloroform phase. The chloroform solution was washed with brine, dried on anhydrous sodium sulphate and evaporated to dryness in vacuo. Yield: 56 g of the title compound, which, recrystallized from ethanol, has a melting point of 112°-113° C.

Provenance & Evidence