Water → HCID 19972408, compound

Participants

Reaction Steps

A solution of 2.5 g of Intermediate X in 25 ml of xylene and 3 ml of dioxane was prepared. 0.15 g of sodium was dissolved in 3.10 ml of anhydrous ethylene glycol, and this solution was added dropwise at ambient temperature to the solution of Intermediate X, and then refluxed for 5.5 hours. The reaction mixture was cooled to ambient temperature, poured into 50 ml of water and extracted with dichloromethane. The extract was washed with a sodium chloride solution, dried on anhydrous sodium sulphate and evaporated to dryness in vacuo. The solid residue was crystallized from ethanol, to give 2.1 g of the title compound, melting point 132°-133° C.

Provenance & Evidence