Water → HCID 54260266, compound

Participants

Reaction Steps

A solution of 6 ml of chloroacetyl chloride in 60 ml of 1,2-dichloroethane was added dropwise at -5°/0° C. to a solution of 20 g of Intermediate XI and 10 ml of triethylamine in 200 ml of 1,2-dichloroethane. After stirring at 20°-25° C. for 2 hours, 150 ml of water was added to the reaction mixture and the phases were separated. The organic phase was washed with water and dried on anhydrous sodium sulphate. The solvent was removed in vacuo, and the residue was crystallized from ethanol to give 22.5 g of the title compound, melting point 146°-148° C.

Provenance & Evidence