o-Nitrophenyl cyclopropyl ketone → (2-Aminophenyl)(cyclopropyl)methanone

HRID 2400177Notes

Reaction equation

HRID 2400177 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[N+:12]([O-])=O)=[O:5])[CH2:3][CH2:2]1.[H][H]>>[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH2:12])=[O:5])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 10487947o-Nitrophenyl cyclopropyl ketoneHCID 178418361HCID 178418361, compound

Product 1

HCID 10931741(2-Aminophenyl)(cyclopropyl)methanone

Procedure

Beneficially, the o-nitrophenyl cyclopropyl ketone may be reduced in the presence of hydrogen and a catalyst to give o-aminophenyl cyclopropyl ketone. The reaction is shown in Flow Diagram II. ##STR2##

Sources & evidence

ORD record
ord-a18da590deb047cd8400240ba5c553f8
Source dataset
uspto-grants-1995_09
Patent number
US05453545

Reaction notes

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