Lithium Hydroxide → HCID 19382503, compound

Participants

Reaction Steps

A mixture of 300 mg of the product from Step 5 and 1.5 mL of 1M LiOH in 12 mL of 5:1 THF/MeOH was stirred for 12 hrs. at r.t. The reaction mixture was then treated with 10 mL of PH-7 buffer and extracted with EtOAc (50 mL). The extract was dried over Na2SO4 and concentrated. The residue was purified by flash chromatography eluted with 2:1 Hexane/EtOAc containing 1% AcOH to give 240 mg of the title compound.

Provenance & Evidence