2,2-Dimethyl-1,3-dioxane-4,6-dione → 8-fluoro-2-oxo-2H-chromene-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

3-Fluorosalicylaldehyde (97.2 mg, 0.69 mmol) and Meldrum's acid (100 mg, 0.69 mmol) were combined in H2O (1 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 99.6 mg of 8-fluoro-3-carboxy-coumarin in a 68% yield.

Provenance & Evidence