HRID2400271

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)O.C[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

HCID3081884

Glatiramer acetate

C25H45N5O13

2 次

PRODUCTS

生成物

结构：C[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

HCID65370

Glatiramer

C23H41N5O11

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID26574

Borate

BO3-3

2 次

PROCEDURE

实验过程

4.8 mg of glatiramer acetate (potency 83% as base for reference standard) were weighed into a 10 ml volumetric flask. Approximately 7 ml of 0.1 M borate buffer were added to afford dissolution of the glatiramer acetate in ultrasonic bath. The solution was further diluted with 0.1M borate buffer to obtain glatiramer stock solution 400 μg/ml (as base).

WORKUP

后处理

customto afford

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-414c3f010bb74b048213c75b7e2d4601
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08796226B2
来源说明: uspto-grants-2014_08

反应 SMILES

[CH3:1][C@H:2]([NH2:6])[C:3]([OH:5])=[O:4].CC(O)=O.[CH:11]1[C:16]([CH2:17][C@H:18]([NH2:22])[C:19]([OH:21])=[O:20])=[CH:15][CH:14]=[C:13]([OH:23])[CH:12]=1.[CH2:24]([CH2:28][C@H:29]([NH2:33])[C:30]([OH:32])=[O:31])[CH2:25][CH2:26][NH2:27].[CH2:34]([C@H:39]([NH2:43])[C:40]([OH:42])=[O:41])[CH2:35][C:36]([OH:38])=[O:37]>B([O-])([O-])[O-]>[CH3:1][C@H:2]([NH2:6])[C:3]([OH:5])=[O:4].[CH:11]1[C:16]([CH2:17][C@H:18]([NH2:22])[C:19]([OH:21])=[O:20])=[CH:15][CH:14]=[C:13]([OH:23])[CH:12]=1.[CH2:24]([CH2:28][C@H:29]([NH2:33])[C:30]([OH:32])=[O:31])[CH2:25][CH2:26][NH2:27].[CH2:34]([C@H:39]([NH2:43])[C:40]([OH:42])=[O:41])[CH2:35][C:36]([OH:38])=[O:37]