2,2-Dimethyl-1,3-dioxane-4,6-dione → 6,7-Dihydroxycoumarin-3-carboxylic Acid

Participants

Reaction Conditions

Reaction Steps

4,5-dihydroxy-salicylaldehyde (213.0 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 271.0 mg of 6,7-dihydroxy-3-carboxy-coumarin in an 88% yield.

Provenance & Evidence