HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240032Generated: October 31, 2026
2,2-Dimethyl-1,3-dioxane-4,6-dione → 7,8-Dimethoxy-3-carboxy-coumarin
https://huagongshe.com/reaction/240032
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Reactant | 3,4-Dimethoxysalicylaldehyde | HCID 87999 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7,8-Dimethoxy-3-carboxy-coumarin | HCID 14954963 | 78% |
Reaction Steps
3,4-dimethoxy-salicylaldehyde (252.8 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 271.0 mg of 7,8-dimethoxy-3-carboxy-coumarin in an 78% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642788B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-1c1d151adb9e46e2b8b59c4bd1951d8d |
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| Source note | uspto-grants-2014_02 |
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