Nitrogen → HCID 44547598, compound

Participants

Reaction Steps

To an evacuated flask back-filled with N2 containing 1-{3-[7-(3-methyl-3H-imidazol-4-ylethynyl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (65.7 mg, 0.15 mmol) in MeOH was added Pd (10 wt % on activated carbon) (25.5 mg). The flask was filled with H2 and the reaction stirred for a total of 7.5 hours. The reaction was filtered and the filtrate concentrated in vacuo. The crude product was purified by preparative HPLC to give pure product (6.1 mg). MS: [M+H]+443.

Provenance & Evidence