HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 7,8-Dimethoxy-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(Imidazo(1,2-a)pyridin-2-yl)aniline | HCID 697021 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 7,8-Dimethoxy-3-carboxy-coumarin | HCID 14954963 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7,8-Dimethoxy-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide | HCID 44197384 | 78% |
Reaction Steps
DIEA (38.3 μL, 0.22 mmol) was added to 7,8-dimethoxy-3-carboxy-coumarin (500 mg, 0.20 mmol) and HATU (83.6 mg, 0.22 mmol) in 1 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine (41.8 mg, 0.20 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 68.7 mg of product in 78% yield: LCMS (ESI) m/z 442 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642788B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-6ed4320365b141d0b1ba4f3e2e877de4 |
| Source note | uspto-grants-2014_02 |