反应详情

A mixture of 2,4 dichloro-5-methoxypyrimidine (0.45 g, 2.5 mmol) and ammonia in methanol (2N, 20 ml) was stirred at room temperature overnight. The mixture was then concentrated in vacuo and washed with water. The residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether) to furnish the title compound as a white solid (211 mg). MS: [M+H]+=160

1. concentrationThe mixture was then concentrated in vacuo
2. washwashed with water
3. customThe residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether)