Methanol → HCID 68162139, compound

Participants

Reaction Steps

To a solution of (3-Iodo-imidazo[1,2-a]pyridin-7-yl)carbamic acid ethyl ester (100 mg, 0.30 mmol) in toluene (0.5 ml) was added 1-[3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea (described in procedure A4) (126 mg, 0.36 mmol), K2CO3 (250 mg, 1.80 mmol), MeOH (0.5 ml), EtOH (0.5 ml) and water (0.7 ml) [reaction degassed by bubbling N2 through]. Bis(tri-tert-butylphosphine)palladium (0) (1.5 mg, 0.003 mmol) was added and the reaction was heated in a CEM discover microwave synthesizer (300W) at 135° C. for 30 min. The mixture was partitioned between water and EtOAc and the organic fraction was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC to give the product (12 mg). MS: [M+H]+=350.

Provenance & Evidence