Glyoxal → 7-[1,2,4]Triazin-3-yl-imidazo[1,2-a]pyridine

Participants

Reaction Steps

To half the material from step d (ca. 2.3 mmol) was added glyoxal (40% in water, 1 ml) and ethanol (15 ml) and the mixture heated to 100 deg C. After 1 hour the reaction was allowed to cool and was concentrated in vacuo. Water and dichloromethane was added and the mixture filtered under suction. The organic liquors were discarded and the aqueous layer was basified with 2N sodium hydroxide solution. To this was added dichloromethane and the mixture was again filtered under suction. The dichloromethane layer was separated and concentrated to furnish 289 mg of a yellow solid (80% clean). MS: [M+H]+198

Provenance & Evidence