HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240036Generated: October 26, 2026
2,2-Dimethyl-1,3-dioxane-4,6-dione → 6-Iodo-3-carboxy-coumarin
https://huagongshe.com/reaction/240036
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Reactant | 5-Iodosalicylaldehyde | HCID 252612 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Iodo-3-carboxy-coumarin | HCID 18996405 | 69% |
Reaction Steps
5-iodosalicylaldehyde (344.2 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 302.0 mg of 6-iodo-3-carboxy-coumarin in 69% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642788B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-fd89cebea6e1418f82f7f52836e62dc4 |
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| Source note | uspto-grants-2014_02 |
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