1-[3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea → HCID 44547899, compound

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Reaction Steps

3-Iodo-7-(5-methyl-[1,2,4]triazin-3-yl)-imidazo[1,2-a]pyridine (120 mg, 0.4 mmol, 1 equiv) and 1-[3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea were coupled according to procedure D4 to furnish the title compound as a yellow solid (85 mg). 1H NMR (400 MHz, DMSO-d6): 9.34 (1H, s), 8.99 (1H, s), 8.74 (1H, d), 8.67 (1H, s), 7.98 (1H, d), 7.93 (1H, s), 7.79 (1H, s), 7.55-7.43 (2H, m), 7.31 (1H, d), 6.87 (1H, t), 3.99-3.88 (2H, m), 2.65 (3H, s). MS: [M+H]+428

Provenance & Evidence