反应详情

温度

-78 °C

Compound 504 (18.0 g, 47.3 mmol) was dissolved in ethanol (300 ml). To the cooled (−78° C.) solution was added boron tribromide (5 eg, 236 mmol) dropwise. After one hour cooling was removed and the mixture was stirred 16 hrs at room temperature. The reaction was quenched with MeOH, the mixture was concentrated in vacuo to give compound 505 as an oil which was used in the next step without further purification.

1. temperatureAfter one hour cooling
2. customwas removed
3. customThe reaction was quenched with MeOH
4. concentrationthe mixture was concentrated in vacuo