HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 44197520, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(Imidazo(1,2-a)pyridin-2-yl)aniline | HCID 697021 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 6-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid | HCID 11481147 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44197520 | HCID 44197520 | 85% |
Reaction Steps
DIEA (46.5 μL, 0.27 mmol) was added to 6-hydroxy-3-carboxy-coumarin (50.0 mg, 0.24 mmol) and HATU (101.4 mg, 0.27 mmol) in 1 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine (50.8 mg, 0.24 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 81.1 mg of product in 85% yield: LCMS (ESI) m/z 398 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642788B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-d6a6d4c662a14e3481264c6e4954194d |
| Source note | uspto-grants-2014_02 |