Dimethylamine → HCID 56655707, compound

HRID 2400447Notes

Reaction equation

HRID 2400447 reaction equation
[CH3:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[F:16])[N:12]=[C:11]([N:17]1[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]1)[NH:10][C:9]2=O.[CH3:33][NH:34][CH3:35]>>[CH3:33][N:34]([CH3:35])[C:9]1[C:8]2[C:13](=[CH:14][C:15]([F:16])=[C:6]([NH:5][CH2:4][C:3]3[C:28]([CH3:32])=[CH:29][CH:30]=[CH:31][C:2]=3[CH3:1])[CH:7]=2)[N:12]=[C:11]([N:17]2[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]2)[N:10]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 136387802HCID 136387802, compound

Product 1

HCID 56655707HCID 56655707, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-((2,6-dimethylbenzyl)amino)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and dimethylamine in step E. MS (ESI): predicted mass calcd. for C23H23FN6O2, 434.2

Sources & evidence

ORD record
ord-2c52dad81d3a4c99ba3609aa119adfd9
Source dataset
uspto-grants-2014_08
Patent number
US08796263B2

Reaction notes

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