Cyclopropylamine → HCID 66747439, compound

HRID 2400474Notes

Reaction equation

HRID 2400474 reaction equation
[CH2:1]([C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][C:17]=1[Cl:18])[N:14]=[C:13]([N:19]1[CH:23]=[C:22]([C:24]([O:26]CC)=[O:25])[CH:21]=[N:20]1)[NH:12][C:11]2=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:30]1([NH2:33])[CH2:32][CH2:31]1>>[CH2:1]([C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][C:17]=1[Cl:18])[N:14]=[C:13]([N:19]1[CH:23]=[C:22]([C:24]([OH:26])=[O:25])[CH:21]=[N:20]1)[N:12]=[C:11]2[NH:33][CH:30]1[CH2:32][CH2:31]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 136379418HCID 136379418, compound

Product 1

HCID 66747439HCID 66747439, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and cyclopropyl amine in step E.MS (ESI): predicted mass calcd. for C22H18ClN5O2, 419.9

Sources & evidence

ORD record
ord-4fc7243ece00496dbeea9e76141047f8
Source dataset
uspto-grants-2014_08
Patent number
US08796263B2

Reaction notes

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