Cyclopropylamine → HCID 68070501, compound

HRID 2400480Notes

Reaction equation

HRID 2400480 reaction equation
[CH3:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[Cl:16])[N:12]=[C:11]([N:17]1[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]1)[NH:10][C:9]2=O.[CH:33]1([NH2:36])[CH2:35][CH2:34]1>>[CH:33]1([NH:36][C:9]2[C:8]3[C:13](=[CH:14][C:15]([Cl:16])=[C:6]([NH:5][CH2:4][C:3]4[C:2]([CH3:1])=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:32])[CH:7]=3)[N:12]=[C:11]([N:17]3[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]3)[N:10]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 136387803HCID 136387803, compound

Product 1

HCID 68070501HCID 68070501, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-((2,6-dimethylbenzyl)amino)-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and cyclopropyl amine in step E. MS (ESI): predicted mass calcd. for C24H23ClN6O2, 462.9

Sources & evidence

ORD record
ord-04471e647c4b4487a86ca2bf201ac48e
Source dataset
uspto-grants-2014_08
Patent number
US08796263B2

Reaction notes

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