HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 8-Trifluoromethoxy-2-oxo-2H-chromene-3-carboxylic acid (3',4'-Dimethoxy-biphenyl-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3',4'-Dimethoxy-[1,1'-biphenyl]-3-amine | HCID 39231855 | — |
| Reactant | 8-Trifluoromethoxy-3-carboxy-coumarin | HCID 86650358 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-Trifluoromethoxy-2-oxo-2H-chromene-3-carboxylic acid (3',4'-Dimethoxy-biphenyl-3-yl)-amide | HCID 86650378 | 66.6% |
Reaction Steps
DIEA (0.0144 mL, 0.072 mmol) was added to 8-trifluoromethoxy-3-carboxy-coumarin (0.018 g, 0.065 mmol) and HATU (0.027 g, 0.072 mmol) in 0.36 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3′,4′-Dimethoxy-biphenyl-3-ylamine (0.015 g, 0.065 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 0.021 g of product in 65% yield: LCMS (ESI) m/z 486 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642788B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-a22d87af41d045e68b7457c47da8ec39 |
| Source note | uspto-grants-2014_02 |