1-Hydroxybenzotriazole → HCID 131731727, compound

Participants

Role	Name	HCID	Charge
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	(2S,5R)-6-(Benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid	HCID 57389355	—
Reactant	HCID 90228933	HCID 90228933	—
Catalyst	4-(Dimethylamino)pyridine	HCID 14284	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 131731727	HCID 131731727	82%

Reaction Steps

To a solution of tert-butyl[(1R,2R)-2-(hydrazinylcarbonyl)cyclopentyl]carbamate 285 (0.15 g, 0.54 mmol) in 20 mL of DCM were added compound 1 (0.2 g, 0.82 mmol), HOBt (0.11 g, 0.82 mmol), DMAP (0.2 g, 1.64 mmol) and EDCl (0.16 g, 0.82 mmol). The mixture was stirred at room temperature for 18 h and purified by column chromatography to afford compound 286 as a solid (0.22 g, 82%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08796257B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-d474c4f06240461aa6d13d5897048215
Source note	uspto-grants-2014_08