N,N-Dimethylaminoethyl chloride hydrochloride → HCID 58530805, compound

HRID 2400774Notes

Reaction equation

HRID 2400774 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:16]3/[C:17](=[O:22])[NH:18][C:19](=[O:21])[S:20]/3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.Cl.Cl[CH2:35][CH2:36][N:37]([CH3:39])[CH3:38]>>[F:32][C:2]([F:31])([F:1])[C:3]1[CH:26]=[C:25]([C:27]([F:29])([F:28])[F:30])[CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:16]3/[C:17](=[O:22])[N:18]([CH2:35][CH2:36][N:37]([CH3:39])[CH3:38])[C:19](=[O:21])[S:20]/3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 86659609HCID 86659609, compound

Product 1

HCID 58530805HCID 58530805, compound

Procedure

(5Z)-5-[(1-{[2,4-Bis(trifluoromethyl)phenyl]methyl}-1H-indazol-5-yl)methylidene]-3-[2-(dimethylamino)ethyl]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 6) and 2-chloro-N,N-dimethylethylamine hydrochloride following General Procedure H.

Sources & evidence

ORD record
ord-acebdd84fc454ed4b4eea473da57ebd2
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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