N,N-Dimethylaminoethyl chloride hydrochloride → HCID 58530701, compound

HRID 2400775Notes

Reaction equation

HRID 2400775 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13](/[CH:17]=[C:18]4/[C:19](=[O:24])[NH:20][C:21](=[O:23])[S:22]/4)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:27]([F:30])([F:29])[F:28])[CH:4]=1.Cl.Cl[CH2:33][CH2:34][N:35]([CH3:37])[CH3:36]>>[CH3:36][N:35]([CH3:37])[CH2:34][CH2:33][N:20]1[C:19](=[O:24])/[C:18](=[CH:17]/[C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:7][C:6]2[CH:25]=[CH:26][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[C:27]([F:30])([F:29])[F:28])[N:9]=[CH:10]3)/[S:22][C:21]1=[O:23]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 86659610HCID 86659610, compound

Product 1

HCID 58530701HCID 58530701, compound

Procedure

(5Z)-3-[2-(Dimethylamino)ethyl]-5-[(1-{[4-(methyloxy)-2-(trifluoromethyl)phenyl]methyl}-1H-indazol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 8) and 2-chloro-N,N-dimethylethylamine hydrochloride following General Procedure H.

Sources & evidence

ORD record
ord-c58e5c6e4f6d4d65bce27490b5d9123f
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

Loading…