1-Bromo-2-Chloroethane → HCID 58530821, compound

HRID 2400780Notes

Reaction equation

HRID 2400780 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13](/[CH:17]=[C:18]4/[C:19](=[O:24])[NH:20][C:21](=[O:23])[S:22]/4)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:27]([F:30])([F:29])[F:28])[CH:4]=1.Br[CH2:32][CH2:33]Cl.[OH:35][C@H:36]1[CH2:40][CH2:39][NH:38][CH2:37]1>>[OH:35][C@H:36]1[CH2:40][CH2:39][N:38]([CH2:32][CH2:33][N:20]2[C:19](=[O:24])/[C:18](=[CH:17]/[C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:7][C:6]3[CH:25]=[CH:26][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[C:27]([F:30])([F:29])[F:28])[N:9]=[CH:10]4)/[S:22][C:21]2=[O:23])[CH2:37]1

Participants

4

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 2733874(3S)-pyrrolidin-3-olHCID 86659610HCID 86659610, compound

Product 1

HCID 58530821HCID 58530821, compound

Procedure

(5Z)-3-{2-[(3S)-3-Hydroxypyrrolidin-1-yl]ethyl}-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 8), 1-bromo-2-chloroethane and (3S)-3-hydroxypyrrolidine following General Procedure G.

Sources & evidence

ORD record
ord-e1afdead309f4534bd6879b206e78d25
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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