1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 58530450, compound

HRID 2400784Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13](/[CH:17]=[C:18]4/[C:19](=[O:24])[NH:20][C:21](=[O:23])[S:22]/4)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:27]([F:30])([F:29])[F:28])[CH:4]=1.Cl.[CH2:32]([N:34]([CH2:37][CH2:38]Cl)[CH2:35][CH3:36])[CH3:33]>>[CH2:32]([N:34]([CH2:37][CH3:38])[CH2:35][CH2:36][N:20]1[C:19](=[O:24])/[C:18](=[CH:17]/[C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:7][C:6]2[CH:25]=[CH:26][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[C:27]([F:30])([F:29])[F:28])[N:9]=[CH:10]3)/[S:22][C:21]1=[O:23])[CH3:33]

Participants

Reactant 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochloride

HCID 86659610HCID 86659610, compound

Product 1

HCID 58530450HCID 58530450, compound

Procedure

(5Z)-3-[2-(Diethylamino)ethyl]-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 8) and N,N-diethylaminoethyl chloride hydrochloride following General Procedure H.

Sources & evidence

ORD record: ord-9e8ba579b2b44881ad84785006df19c9
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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