Methanesulfonamide → HCID 58530861, compound

HRID 2400786Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:35]=[CH:34][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13](/[CH:17]=[C:18]4/[C:19](=[O:33])[N:20]([CH:24]5[CH2:29][CH2:28][CH:27]([C:30]([OH:32])=O)[CH2:26][CH2:25]5)[C:21](=[O:23])[S:22]/4)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:36]([F:39])([F:38])[F:37])[CH:4]=1.[CH3:40][S:41]([NH2:44])(=[O:43])=[O:42]>>[CH3:1][O:2][C:3]1[CH:35]=[CH:34][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13](/[CH:17]=[C:18]4/[C:19](=[O:33])[N:20]([CH:24]5[CH2:25][CH2:26][CH:27]([C:30]([NH:44][S:41]([CH3:40])(=[O:43])=[O:42])=[O:32])[CH2:28][CH2:29]5)[C:21](=[O:23])[S:22]/4)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:36]([F:37])([F:39])[F:38])[CH:4]=1

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 58530759HCID 58530759, compound

Product 1

HCID 58530861HCID 58530861, compound

Procedure

4-[(5Z)-5-({1-[4-Methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(methylsulfonyl)cyclohexanecarboxamide was prepared from 4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid (Example 22) following General Procedure L using methanesulfonic acid amide in place of the sulfamide.

Sources & evidence

ORD record: ord-d9a643dcff4c435ebd44b7d91ca81ced
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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