Potassium Carbonate → HCID 58530894, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of [(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 6; 0.064 mmol), 1-(2-chloroethyl)-1H-[1,2,4]triazole (0.096 mmol), K2CO3 (0.128 mmol) in DMF (1 mL) was heated in a microwave reactor at 140° C. for 10 min, then cooled to rt and concentrated in vacuo. The resultant residue was purified by silica gel chromatography (DCM/MeOH) to afford (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[2-(1H-1,2,4-triazol-1-yl)ethyl]-1,3-thiazolidine-2,4-dione as a yellow solid.

Provenance & Evidence