1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde → HCID 58530929, compound

HRID 2400802Notes

Reaction equation

HRID 2400802 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][N:8]1[C:12](=[O:13])[CH2:11][S:10][C:9]1=[O:14].[F:15][C:16]([F:40])([F:39])[C:17]1[CH:34]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:32]=[CH:31][C:18]=1[CH2:19][N:20]1[C:28]2[C:23](=[CH:24][C:25]([CH:29]=O)=[CH:26][CH:27]=2)[CH:22]=[N:21]1>>[F:40][C:16]([F:15])([F:39])[C:17]1[CH:34]=[C:33]([C:35]([F:36])([F:37])[F:38])[CH:32]=[CH:31][C:18]=1[CH2:19][N:20]1[C:28]2[C:23](=[CH:24][C:25](/[CH:29]=[C:11]3/[C:12](=[O:13])[N:8]([CH2:7][C@@H:3]4[CH2:4][CH2:5][CH2:6][N:2]4[CH3:1])[C:9](=[O:14])[S:10]/3)=[CH:26][CH:27]=2)[CH:22]=[N:21]1

Participants

3

Reactant 2

HCID 866545381-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehydeHCID 86659619HCID 86659619, compound

Product 1

HCID 58530929HCID 58530929, compound

Procedure

(5Z)-5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{[(2S)-1-methylpyrrolidin-2-yl]methyl}-1,3-thiazolidine-2,4-dione was prepared from {[(2S)-1-methylpyrrolidin-2-yl]methyl}-1,3-thiazolidine-2,4-dione (from Example 23) and [2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 6) following General Procedure F.

Sources & evidence

ORD record
ord-dfab91caf2ca4247b7983673d8eaca4d
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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