N,N-Dimethylsulfamide → HCID 58530832, compound

HRID 2400807Notes

Reaction equation

[F:1][C:2]([F:36])([F:35])[C:3]1[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:16]3/[C:17](=[O:26])[N:18]([CH2:22][C:23](O)=[O:24])[C:19](=[O:21])[S:20]/3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[CH3:37][N:38]([CH3:43])[S:39]([NH2:42])(=[O:41])=[O:40]>>[F:1][C:2]([F:36])([F:35])[C:3]1[CH:30]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:28]=[CH:27][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:16]3/[C:17](=[O:26])[N:18]([CH2:22][C:23]([NH:42][S:39](=[O:41])(=[O:40])[N:38]([CH3:43])[CH3:37])=[O:24])[C:19](=[O:21])[S:20]/3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

Reactant 2

HCID 134472N,N-Dimethylsulfamide

HCID 58530630HCID 58530630, compound

Product 1

HCID 58530832HCID 58530832, compound

Procedure

2-[(5Z)-5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(dimethylsulfamoyl)acetamide was prepared from {5-[1-(2,4-bis-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid (Example 59) and N,N-dimethylsulfamide following General Procedure L.

Sources & evidence

ORD record: ord-ec791926009c4b21b18dc7dbc010a14c
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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