(+-)-3-Quinuclidinol → HCID 58530624, compound

HRID 2400813Notes

Reaction equation

HRID 2400813 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.O[CH:31]1[CH:36]2[CH2:37][CH2:38][N:33]([CH2:34][CH2:35]2)[CH2:32]1>>[N:33]12[CH2:38][CH2:37][CH:36]([CH2:35][CH2:34]1)[CH:31]([N:19]1[C:18](=[O:23])/[C:17](=[CH:16]/[C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:24]=[CH:25][C:2]([Cl:1])=[CH:3][C:4]=3[C:26]([F:27])([F:29])[F:28])[N:8]=[CH:9]4)/[S:21][C:20]1=[O:22])[CH2:32]2

Participants

3

Reactant 2

HCID 15381(+-)-3-QuinuclidinolHCID 86659608HCID 86659608, compound

Product 1

HCID 58530624HCID 58530624, compound

Procedure

(5Z)-3-(1-Azabicyclo[2.2.2]oct-3-yl)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and 3-hydroxy-1-azabicyclo[2.2.2]octane following General Procedure J.

Sources & evidence

ORD record
ord-aab8541f69b9427bbbf373a53fdca9a2
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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