1-Bromo-2-Chloroethane → HCID 58530474, compound

HRID 2400814Notes

Reaction equation

HRID 2400814 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Br[CH2:31][CH2:32]Cl.Cl.[OH:35][CH:36]1[CH2:39][NH:38][CH2:37]1>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([CH2:31][CH2:32][N:38]5[CH2:39][CH:36]([OH:35])[CH2:37]5)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:27])([F:29])[F:28])[CH:3]=1

Participants

4

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 27592903-Hydroxyazetidine hydrochlorideHCID 86659608HCID 86659608, compound

Product 1

HCID 58530474HCID 58530474, compound

Procedure

(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}-methylidene)-3-[2-(3-hydroxyazetidin-1-yl)ethyl]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1), 1-bromo-2-chloroethane and 3-hydroxyazetidine hydrochloride following General Procedure G.

Sources & evidence

ORD record
ord-3dc1cc512dd246d59f4654aedd6c7622
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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