1-Bromo-2-Chloroethane → HCID 58530564, compound

HRID 2400819Notes

Reaction equation

[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Br[CH2:31][CH2:32]Cl.Cl.[NH:35]1[CH2:38][CH2:37][CH2:36]1>>[N:35]1([CH2:31][CH2:32][N:19]2[C:18](=[O:23])/[C:17](=[CH:16]/[C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:24]=[CH:25][C:2]([Cl:1])=[CH:3][C:4]=3[C:26]([F:27])([F:29])[F:28])[N:8]=[CH:9]4)/[S:21][C:20]2=[O:22])[CH2:38][CH2:37][CH2:36]1

Participants

Reactant 3

HCID 78491-Bromo-2-Chloroethane

HCID 12308726Azetidine hydrochloride

HCID 86659608HCID 86659608, compound

Product 1

HCID 58530564HCID 58530564, compound

Procedure

(5Z)-3-(2-Azetidin-1-ylethyl)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1), 1-bromo-2-chloroethane and azetidine hydrochloride following General Procedure G.

Sources & evidence

ORD record: ord-dbf05d266d0b4475803016a8efe7e5ae
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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