2-(2-Chloroethyl)-1-methylpyrrolidine → HCID 58530552, compound

HRID 2400834Notes

Reaction equation

HRID 2400834 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Cl[CH2:31][CH2:32][CH:33]1[CH2:37][CH2:36][CH2:35][N:34]1[CH3:38]>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([CH2:31][CH2:32][CH:33]5[CH2:37][CH2:36][CH2:35][N:34]5[CH3:38])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:27])([F:29])[F:28])[CH:3]=1

Participants

3

Reactant 2

HCID 2850932-(2-Chloroethyl)-1-methylpyrrolidineHCID 86659608HCID 86659608, compound

Product 1

HCID 58530552HCID 58530552, compound

Procedure

(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[2-(1-methylpyrrolidin-2-yl)ethyl]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and 2-(2-chloroethyl)-1-methylpyrrolidine following General Procedure H.

Sources & evidence

ORD record
ord-d8376f0379304ae6a9063dd2564d4f18
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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