rel-Ethyl (1R,2S)-2-hydroxycyclopentanecarboxylate → HCID 58530957, compound

HRID 2400835Notes

Reaction equation

HRID 2400835 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.O[C@H:31]1[CH2:35][CH2:34][CH2:33][C@H:32]1[C:36]([O:38][CH2:39][CH3:40])=[O:37]>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([C@@H:31]5[CH2:35][CH2:34][CH2:33][C@H:32]5[C:36]([O:38][CH2:39][CH3:40])=[O:37])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:27])([F:29])[F:28])[CH:3]=1

Participants

3

Reactant 2

HCID 2724648rel-Ethyl (1R,2S)-2-hydroxycyclopentanecarboxylateHCID 86659608HCID 86659608, compound

Product 1

HCID 58530957HCID 58530957, compound

Procedure

Ethyl (1R,2R)-2-[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclopentanecarboxylate was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and ethyl (1R,2S)-2-hydroxycyclopentanecarboxylate following General Procedure J.

Sources & evidence

ORD record
ord-4b83ec30f76f4719aa8c9e0b29e6647c
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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