2-(Methylsulfonyl)ethyl methanesulfonate → HCID 58530724, compound

HRID 2400847Notes

Reaction equation

HRID 2400847 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:29])[N:19]([CH2:23][C@@H:24]5[CH2:28][CH2:27][CH2:26][NH:25]5)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:32]([F:35])([F:34])[F:33])[CH:3]=1.CS(O[CH2:41][CH2:42][S:43]([CH3:46])(=[O:45])=[O:44])(=O)=O>>[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:29])[N:19]([CH2:23][C@@H:24]5[CH2:28][CH2:27][CH2:26][N:25]5[CH2:41][CH2:42][S:43]([CH3:46])(=[O:45])=[O:44])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:32]([F:35])([F:33])[F:34])[CH:3]=1

Participants

3

Reactant 2

HCID 184645972-(Methylsulfonyl)ethyl methanesulfonateHCID 86659622HCID 86659622, compound

Product 1

HCID 58530724HCID 58530724, compound

Procedure

(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-({(2S)-1-[2-(methylsulfonyl)ethyl]pyrrolidin-2-yl}methyl)-1,3-thiazolidine-2,4-dione was prepared from (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(2S)-pyrrolidin-2-ylmethyl]-1,3-thiazolidine-2,4-dione (Example 145) and 2-(methylsulfonyl)ethyl methanesulfonate (prepared as described in WO 2006/047277) following General Procedure S.

Sources & evidence

ORD record
ord-ca27b5115b694738b54c8944507a0872
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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