HCID 86659624, compound → HCID 58530618, compound

HRID 2400849Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C@H:7]([N:11]1[C:19]3[C:14](=[CH:15][C:16]([CH:20]=O)=[CH:17][CH:18]=3)[CH:13]=[N:12]1)[CH2:6][CH2:5]2.[N:22]1([CH2:27][CH2:28][N:29]2[C:33](=[O:34])[CH2:32][S:31][C:30]2=[O:35])[CH2:26][CH2:25][CH2:24][CH2:23]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C@H:7]([N:11]1[C:19]3[C:14](=[CH:15][C:16](/[CH:20]=[C:32]4/[C:33](=[O:34])[N:29]([CH2:28][CH2:27][N:22]5[CH2:26][CH2:25][CH2:24][CH2:23]5)[C:30](=[O:35])[S:31]/4)=[CH:17][CH:18]=3)[CH:13]=[N:12]1)[CH2:6][CH2:5]2

Participants

Reactant 2

HCID 86659624HCID 86659624, compound

HCID 86659625HCID 86659625, compound

Product 1

HCID 58530618HCID 58530618, compound

Procedure

(5Z)-5-({1-[(1R)-5-Chloro-2,3-dihydro-1H-inden-1-yl]-1H-indazol-5-yl}methylidene)-3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione was prepared by the method described for Example 172, using the isomeric (1R)-(5-chloroindan-1-yl)-1H-indazole-5-carbaldehyde and 3-(2-pyrrolidin-1-ylethyl)-1,3-thiazolidine-2,4-dione following General Procedure F.

Sources & evidence

ORD record: ord-9c92b671f3a54c80a01a160e465e5bbf
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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