1-Bromo-2-Chloroethane → HCID 58530518, compound

HRID 2400872Notes

Reaction equation

HRID 2400872 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:16]3/[C:17](=[O:22])[NH:18][C:19](=[O:21])[S:20]/3)=[CH:12][CH:13]=2)[CH:8]=[CH:7]1.Br[CH2:34][CH2:35]Cl.[NH:37]1[CH2:44][CH2:43][CH2:42][C@@H:38]1[C:39]([OH:41])=[O:40]>>[F:32][C:2]([F:1])([F:31])[C:3]1[CH:26]=[C:25]([C:27]([F:29])([F:30])[F:28])[CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:16]3/[C:17](=[O:22])[N:18]([CH2:43][CH2:44][N:37]4[CH2:35][CH2:34][CH2:42][C@@H:38]4[C:39]([OH:41])=[O:40])[C:19](=[O:21])[S:20]/3)=[CH:12][CH:13]=2)[CH:8]=[CH:7]1

Participants

4

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 8988D-ProlineHCID 86659630HCID 86659630, compound

Product 1

HCID 58530518HCID 58530518, compound

Procedure

1-{2-[(5Z)-5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl}-D-proline was prepared from [(5Z)-5-({1-[2,4-bis-(trifluoromethyl)benzyl]-1H-indol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 238), 2-bromo-1-chloroethane and (D)-proline following General Procedure G.

Sources & evidence

ORD record
ord-bb153b12bc4045b3ae0ee836287feea8
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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