N,N-Dimethylaminoethyl chloride hydrochloride → HCID 58530896, compound

HRID 2400873Notes

Reaction equation

HRID 2400873 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Cl.[CH3:31][N:32]([CH3:36])[CH2:33][CH2:34]Cl>>[CH3:31][N:32]([CH3:36])[CH2:33][CH2:34][N:19]1[C:18](=[O:23])/[C:17](=[CH:16]/[C:12]2[CH:11]=[C:10]3[C:15](=[CH:14][CH:13]=2)[N:7]([CH2:6][C:5]2[CH:24]=[CH:25][C:2]([F:1])=[CH:3][C:4]=2[C:26]([F:29])([F:27])[F:28])[CH:8]=[CH:9]3)/[S:21][C:20]1=[O:22]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 86659633HCID 86659633, compound

Product 1

HCID 58530896HCID 58530896, compound

Procedure

(5Z)-3-[2-(Dimethylamino)ethyl]-5-[(1-{[4-fluoro-2-(trifluoromethyl)-phenyl]methyl}-1H-indol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-fluoro-2-(trifluoromethyl)benzyl]-1H-indol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 249) and 2-(dimethylamino)ethyl chloride hydrochloride following General Procedure H.

Sources & evidence

ORD record
ord-4973a599e45b4515bac2fb97479d689f
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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