HCID 14198890, compound → HCID 58530408, compound

HRID 2400893Notes

Reaction equation

HRID 2400893 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=O)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.O1CCCCC1[O:33][N:34]1[C:38](=[O:39])[CH2:37][S:36][C:35]1=[O:40]>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:37]3/[C:38](=[O:39])[N:34]([OH:33])[C:35](=[O:40])[S:36]/3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 14198890HCID 14198890, compoundHCID 866545381-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 58530408HCID 58530408, compound

Procedure

(5Z)-5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-hydroxy-1,3-thiazolidine-2,4-dione was prepared from [2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 6) and 3-(tetrahydropyran-2-yl)oxy-1,3-thiazolidine-2,4-dione (from Example 288) following General Procedure F.

Sources & evidence

ORD record
ord-d8a53918753f49f5a6f7b08f0539a88f
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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