Dimethylamine → HCID 86659653, compound

HRID 2400894Notes

Reaction equation

[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](=[O:22])[N:19]([CH2:23][C@@H:24]([OH:31])[CH2:25][N:26]5[CH2:30]CC[CH2:27]5)[C:18]4=[O:32])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:35]([F:38])([F:37])[F:36])[CH:3]=1.CNC>>[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](=[O:22])[N:19]([CH2:23][C@@H:24]([OH:31])[CH2:25][N:26]([CH3:30])[CH3:27])[C:18]4=[O:32])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:35]([F:37])([F:36])[F:38])[CH:3]=1

Participants

Reactant 2

HCID 674Dimethylamine

HCID 86659654HCID 86659654, compound

Product 1

HCID 86659653HCID 86659653, compound

Procedure

5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-3-[(2S)-3-dimethylamino-2-hydroxypropyl]thiazolidine-2,4-dione was prepared from 5-[1-(4-chloro-2-trifluoromethyl benzyl)-1H-indazol-5-ylmethylene]-3-(R)-oxiranylmethylthiazolidine-2,4-dione (from Example 292) and dimethylamine following General Procedure X.

Sources & evidence

ORD record: ord-904deefbaa454dad87ad10a97d383f8b
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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