2-Fluoroethylamine → HCID 86659655, compound

HRID 2400895Notes

Reaction equation

[Cl:1][C:2]1[CH:35]=[CH:34][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](=[O:22])[N:19]([CH2:23][C@H:24]([OH:32])[CH2:25][N:26]5CC[C@@H:28]([F:31])[CH2:27]5)[C:18]4=[O:33])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:36]([F:39])([F:38])[F:37])[CH:3]=1.FCCN>>[Cl:1][C:2]1[CH:35]=[CH:34][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](=[O:22])[N:19]([CH2:23][C@H:24]([OH:32])[CH2:25][NH:26][CH2:27][CH2:28][F:31])[C:18]4=[O:33])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:36]([F:38])([F:37])[F:39])[CH:3]=1

Participants

Reactant 2

HCID 99962-Fluoroethylamine

HCID 86659656HCID 86659656, compound

Product 1

HCID 86659655HCID 86659655, compound

Procedure

5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-3-[(2R)-3-(2-fluoroethylamino)-2-hydroxypropyl]thiazolidine-2,4-dione was prepared from 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-3-(S)-oxiranylmethylthiazolidine-2,4-dione (from Example 294) and 2-fluoroethylamine following General Procedure X.

Sources & evidence

ORD record: ord-eefdb3763f11442eb232123a2221b658
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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