(2S)-1-Methyl-2-pyrrolidinemethanol → (5Z)-5-({3-Chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}-methylidene)-3-{[(2S)-1-methylpyrrolidin-2-yl]methyl}-1,3-thiazolidine-2,4-dione

Participants

Role	Name	HCID	Charge
Reactant	(2S)-1-Methyl-2-pyrrolidinemethanol	HCID 643492	—
Reactant	[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-chloro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid	HCID 58530566	—
Product	(5Z)-5-({3-Chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}-methylidene)-3-{[(2S)-1-methylpyrrolidin-2-yl]methyl}-1,3-thiazolidine-2,4-dione	HCID 58530700	—

Reaction Steps

(5Z)-5-({3-Chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}-methylidene)-3-{[(2S)-1-methylpyrrolidin-2-yl]methyl}-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({3-chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 287) and (2S)-(−)-1-methyl-2-pyrrolidinemethanol following General Procedure J.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08796256B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-f41d8eb69aef44cd8d262465506fb30a
Source note	uspto-grants-2014_08