Ethyl 4-hydroxycyclohexanecarboxylate → 4-[(5Z)-5-({3-Chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid ethyl ester

HRID 2400904Notes

Reaction equation

[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:27])[N:19]([CH2:23]C(O)=O)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[C:9]([Cl:28])=[N:8]2)=[C:4]([C:31]([F:34])([F:33])[F:32])[CH:3]=1.[CH2:35]([O:37][C:38]([CH:40]1[CH2:45][CH2:44]C(O)[CH2:42][CH2:41]1)=[O:39])[CH3:36]>>[CH2:35]([O:37][C:38]([CH:40]1[CH2:45][CH2:44][CH:23]([N:19]2[C:18](=[O:27])/[C:17](=[CH:16]/[C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:29]=[CH:30][C:2]([Cl:1])=[CH:3][C:4]=3[C:31]([F:34])([F:33])[F:32])[N:8]=[C:9]4[Cl:28])/[S:21][C:20]2=[O:22])[CH2:42][CH2:41]1)=[O:39])[CH3:36]

Participants

Reactant 2

HCID 86973Ethyl 4-hydroxycyclohexanecarboxylate

HCID 58530566[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-3-chloro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid

Product 1

HCID 866596634-[(5Z)-5-({3-Chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid ethyl ester

Procedure

4-[(5Z)-5-({3-Chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid ethyl ester was prepared from [(5Z)-5-({3-chloro-1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 287) and 4-hydroxycyclohexanecarboxylic acid ethyl ester following General Procedure J.

Sources & evidence

ORD record: ord-b1bac4bd4d984c93b2622e8e65104d1e
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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